Critically analysing the issues and effectiveness of the Code of Essay

Critically analysing the issues and effectiveness of the Code of Sustainable Homes and their contribution to helping UK Government to achieve the reductions in CO2 required - Essay Example necessitates the need to formulate strategies, framework, policies, regulations and any other method to reduce the emission of greenhouse gases in to the atmosphere (Bergman et al, 2007). Presently the world is going through the global warming phase; the cause has been attributed to increasing green house gases from industrial, commercial and various other residential activities. Goodall (2007:3) mentions that fewer people know the details regarding the amount of carbon dioxide are generated in their day to day activities. It is further mentioned that only air travels, each person travelling by air is responsible for 12.5 tonnes of greenhouse gases per year in United Kingdom. It is important to mention that half of the total carbon emissions results from the way in which we live i.e. running our homes and getting from place to place in car or plane. Bergman et al (2007) states that household ownership of electronics, such as televisions, domestic IT and other gadgets has increased ra pidly and expected to continue to rise over the next years making the consumer electronics, the biggest single sector of home electricity consumption. And moreover, the number of households is increasing with the increased growth in population year by year causing an increased environmental burden and introducing social sustainability issues. It is further mentioned that the one person household in the UK has grown from 18% in 1971 to 30% in 2001 and are predicted to constitute 38% of households by 2026. In view of the involvement of residential activities in carbon emissions and other greenhouse gases, the governments from different countries evolved and formulated different strategies to cope with the increasing problem. The present paper looks into the policies adopted by United Kingdom to reduce the carbon emissions the residential sector by providing carbon free homes as stipulated in their Code for Sustainable Homes. According to the report for World Business Summit on Climate

Badly behaved pupils and parents put teachers off Essay Example for Free

Badly behaved pupils and parents put teachers off Essay Suggestions have been raised over the child benefits in United States. For example, Iain Duncan Smith’s suggested that child-related benefits should be limited to two offspring in a family. The fight against the child benefits aren’t justified as they are ill treated. The move should be encouraged as it has helped a good number of the families in the country, in addition limiting the benefit to only a handful (two) children in a family, it doesn’t really play the intended role in the society. Contrary to this, the government should be encouraged to continue with the child benefits program as it has been a gain to a big number of families. Despite the need to have family planning aspects among the people to control the number of children at each family, the child benefit from the government should still remain (Liz, 2014). Child benefit or better still child allowance is a social security payment distributed to parents, children or guardians which highly dependent on the number of children in a family. the child benefit has been effective in helping to support children from less advantaged families which has enables them access essential human needs such a education, food and such. The anti- child benefit campaigns should be shunned as the move is more beneficial to a good number of people and children in the society. Scrubbing the project would land more families especially the poor ones which cannot afford human basic wants. In other words it is the cash expenditure to families with kids not considering their parents income. The advantage amount may vary by the ordinal arrangement of the child, the age of the child, and/or the employment status of the parent. In addition to being of great benefit to the families and children, the benefit helps with extra cost to the families on the extra cost of children. The benefit also includes benefits for women who are pregnant or who have just given birth. The benefits are also helpful to partners whose partners have given birth, people who adopt, tax credits among other benefits. The benefit is essential when one has a responsibility for a child or a young person. In addition to child benefit, there is also the child tax credit. The benefit is also intertwined with the guardians allowances as well as both are meant to help children below the age of 18. The redeployment of income from childless households to families with children, in appreciation of the heavier financial weight incurred by child-rearing (Liz, 2014). Moreover, in order to enjoy the benefits of the child benefit, the benefiting families aren’t required to contribute any national insurance contribution and this in turn comes as gain to the poor families. In addition, the benefit isn’t offered to children who might be under the custody or in prison. In case of child death that was on the child benefit plan, the benefits continue to be given to the family for the next eight weeks. However, despite the benefit behind the child benefit payment, families should be encouraged to practice family planning in order to be able to raise the number of children whom they can comfortably support. The move is however, beneficial in case of calamities such as misfortunes and unemployment’s incase of the parents (Liz, 2014). The child benefit has been beneficial and should be maintained in order to keep boosting the upbringing of the children especially in the financially unstable family. In addition, when the parents loose their jobs they still have the chance to provide for their children, such as food and education. The benefit for the program is numerous and they outweigh the downside of the program. This program is one of the government programs for the grants to the people which have gone miles in assisting less fortunate families financially. A good number countries offer higher benefits levels or supplements for children with disabilities. Family allowances and child benefits are viewed as an instrument that can foster societal cohesion and progress and in turn should be maintained. The benefits also help in strengthening labor force attachments in the country and hence shouldn’t be abolished. Last and not the least, the benefit helps in supplementing the incomes of poor and modest income families with children as a means of reducing or preventing poverty. In conclusion, it’s clear that, the child benefit program is more beneficial to community, and in turn should be maintained. This means the anti-child benefit campaigns should be shunned as the program is of great help to the people. Article (II) Student Behaviour One of the driving forces behind the motivation of teachers in the school is the student behaviours. Badly behaved students are subject to putting off their teachers from the teaching profession. Teachers and school staff understands the changes encountered by students in school and provides them with relevant information and support needed. However, the dedication of the teachers and the staff depends much on the student behaviour and in most cases good behaved students encourages their teachers into the teaching profession. Contrary to this, badly behaved students and teachers are a discouraging factor to the teachers as they put them off from the teaching profession. It is ‘however’ true the student behaviour plays an important role in motivating and maintaining teachers into the profession. The survey is a true reflection of the teachers experience and the parent’s negligence in moulding their children’s behaviour (Jessica, 2014). ‘Badly behaved pupils and parents put teachers off’ was a survey conducted by Guardian Teacher Networks which shows that a good number of teachers have once in awhile considered quitting the profession. Student and parent’s behaviour are essential towards the teacher’s performance in schools. A good number of schools have issues in reference to student behaviours in recent years, which have become a vital problem in modern society. One of factors behind poor student behaviours is collapse of family functions such as divorced family, single parenthood, and children becomes isolated. This in turn leads to bad behaviour among parents and/or students, which de-motivates the teachers. According to the survey, it is clear that, the student or the pupil’s behaviours directly influence the performance of the teachers. Bad behaviour among parents and pupils would negatively influence the teachers and in turn them off from the work. Students who develop behavioural problems from their families are a discouraging aspect to the teachers. It is believed that, pupils/learns important skills and knowledge such as morals and wisdom, which are normally learned from their parents. The survey shows that, the student behaviour is one of the driving factors behind motivated and dedicated teachers (Jessica, 2014). One of the effects of bad student behaviour is that it interferes with individual and other learner’s behaviour. This turns to a challenge for the teacher, as the behaviour challenges day to day running and functioning of schools. In addition, the parents are not helping as much as they would in eradicating negative student and pupils behaviours, hence burdening the work of the teachers purporting them to consider leaving their jobs. Nowadays, the parents have become overprotective to their children. This has not helped at all in taming negative children behaviours and in turn, the burden is left to the teacher to mould the children’s behaviour. For example, an overprotected child expects special treatment at school is in for a frustrating time, which in turn may frustrate the teacher too. The frustration may overwhelm the teacher to a point of making the job dissertation choice. In addition, parents have developed negative expectations for their children which in turn instill negative or unruly behavior in children. From the survey conducted, it’s clearly evident that, If unruly behavior is not policed with proper boundaries and a culture of respect for authority at home, teachers cannot effectively implement discipline in the classroom. In addition to negative learner’s behavior, the interference from the government demands of the teacher. 50 % of the interviewed teachers named poor pupil behavior as the main reason behind them leaving the teaching job. The unwanted student behavior influences teachers attitude towards the teaching profession, and if the unruly behavior continues, it may force the teachers to quit the teaching job. Attitude provides a frame for reference for an individual’s conduct and conditions behavior. The creation of unfavorable attitude to the teacher, elicits a reaction of avoidance or aggression towards the job or the learners (Jessica, 2014). In conclusion, it’s clear that, student and parents behavior towards the teachers as well as in the school plays a vital role in molding the teachers. The study reveals that, teacher’s motivation into teaching profession is highly dependent on the children or the learner’s behaviors. The parents are making the scenario worse by failing to support the teachers in the in order to change the learner’s negative behavior into acceptable ones. These demands and the stress accompanying the works force the teacher to quit. The survey, however suggests that since its is disruptive children whose behavior is unchecked who miss out the most on their education. Thats why we want to make sure that teachers have more freedom to clamp down on persistently bad behavior without being hampered by bureaucracy, so that teaching time is not lost because of poor behavior, and in turn prevent a stressing profession to the teachers. This would go miles in improving both the teach ers and students performance in the school. References Liz Jones. You dont pay for my cats so why should I pay for your kids? Retrieved from: http://www.dailymail.co.uk/debate/article-2224260/LIZ-JONES-You-dont-pay-catsI-pay-kids.html. On Tuesday 1 April 2014. Jessica Shepherd, ‘Badly behaved pupils and parents put teachers off’ ’ badly behaved pupils and parents put teachers off: retrieved from http://www.theguardian.com/education/2011/oct/03/teaching-poll-behaviour. On Tuesday 1 April 1, 2014. Source document

Enantioselective Disposition of MDMA and its Metabolites

Enantioselective Disposition of MDMA and its Metabolites INTRODUCTION Amphetamine-type stimulants (ATS) are a group of drugs, mostly synthetic in origin, that are structurally derived from ÃŽ ²-phenethylamine (Figure 1). Amphetamine (AMP, Speed) was initially synthesized in Berlin in 1887 as 1-methyl-2-phenethylamine. It was the first of several chemicals, including methamphetamine (MET, Ice) and 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy), which have similar structures and biological properties, and are referred to collectively as amphetamines (Cody, 2005). Since 1887, amphetamine was thought to be a human invention (Berman et al., 2009), but the compound was found in 1997, along with methamphetamine, nicotine and mescaline, within two species of Texas acacia bushes (Clement, Goff and Forbes, 1998). AMP and MET are most commonly abused drugs. They have asymmetric centre and exists as one of the two possible enantiomers (see Figure 2) (Cody, 2005). In attempt to maintain anorexic activity while limiting undesirable side effects, substitutions have been made to amphetamine and methamphetamine. Others have been made to enhance the stimulatory activity or to avoid legal restrictions on the manufacture and use of the drugs (Cody, 2005). The related groups of amphetamine derivatives are shown in Figures 3 and 4. Figure 5 shows another group of precursor drugs that is metabolized by the body into AMP and MET. Administration and neurotoxicity of amphetamines Amphetamines are generally administered as oral capsules. This route results in a gradual increase in drug concentration, which peaks in around an hour and maintains effective drug levels for 8 – 12 hours. Amphetamines can also be injected into the circulation (Parrott et al., 2004). Amphetamines readily cross the blood-brain barrier to reach the sites (Berman et al., 2009) of action in the brain. The acute administration of amphetamines produce a wide range of dose-dependent behavioral changes, including increased arousal or wakefulness, anorexia, hyperactivity, perseverative movements, and, in particular, a state of pleasurable affect, elation, and euphoria, which can lead to the abuse of the drug (Berman, 2009). This causes amphetamines to be associated with acts of violence. Acute drug abusers will develop tolerance, where the same dose of drug has diminishing physiological and psychological effects. They need to increase their dosage if they wish to generate the same stre ngth of effect. Cross-tolerance will also occur as tolerance to one drug affects another drug with similar neurochemical profile. As a result, drug abusers will seek for another class of drug and become polydrug users (Parrott et al., 2004). Chronic drug abusers usually take in amphetamines through injection or smoking ice amphetamines. These abusers suffer many health problems and a reduced life expectancy. They are more susceptible to HIV (human immunodeficiency virus), AIDS (acquired immunity deficiency syndrome) and SIDS (sudden infant death syndrome) (Parrott at al., 2004). Clinical uses In accordance with the Convention on Psychotropic Substances of 1971, amphetamines are enlisted as narcotic compounds in the List of psychotropic substances under international control. The list is prepared by the International Narcotics Control Board. These compounds are prohibited to be imported and exported in countries like Japan, Nigeria, Pakistan, Thailand and etc (International Narcotics Control Board, 2003). Amphetamines and related compounds are clinically used for narcolepsy (sudden day-time onset sleep) and Attention Deficit Hyperactivity Disorder (ADHD) in young children. It was formerly used as a short-term slimming agent, as an antidepressant and to boost athletic performance (Parrott et al., 2004). 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA, ECSTASY) History of MDMA abuse MDMA, also known as ecstasy, ETC, or Adam, is one of the most commonly abused amphetamine derivatives that was re-synthesised by Alexander Shulgin during his research career at the Dow Chemical Company in 1970s. Soon MDMA was being synthesised in illicit laboratories, and became popular as recreational drug since then. As MDMA does not have any clinical/medical use, it is scheduled as Class I illicit drug by the American Drug Enforcement Agency in 1985 (Parrott et al., 2005). Also, MDMA other ring-substituted phenylethylamines were generically classified under the Misuse of Drugs Act as Class A drugs, in United Kingdom (Wikipedia, 2009). Chemical Properties of MDMA The methylenedioxy analogues of amphetamine (see Figure 3) are series of compounds referred to designer drugs. They include methylenedioxyamphetamine (MDA), methylenedioxyethylamphetamine (MDEA) and MDMA (Hensley and Cody, 1999). The synthesis of N-alkyl-MDA derivatives only produces ( ±) racemic mixtures. As a results, only racemic forms of (capsules, loose powder or tablets) the compounds are sold in the illicit market and abused (Matsushima, Nagai and Kamiyama, 1998; Fallon et al., 1999). MDMA is chiral, possessing two enantiomers, S-(+)-MDMA and R-(-)-MDMA (see Figure 6), with S-(+)-MDMA is more potent than R-(-)-MDMA (Lyon, Glannon and Titeller, 1986; Shulgin 1986). The basic structure of MDMA is ?-phenylisopropylamine group (see Figure 6), with a methylenedioxy group forming a 5-membered ring including C-3 and C-4 of the benzene ring (Cho and Segal, 1994). The empirical formula of MDMA is C11H15NO2 (Shulgin, 1986). MDMA is a phenylisopopylamine derived from safrole, aromatic oil found in sassafras, nutmeg, and other plants. The methyl group on ÃŽ ±-carbon (R2) (see Figure 6) of MDMA confers resistance to oxidative deamination of this compound and, therefore, increased its metabolic half-life (Cho and Segal, 1994). According to Cone and his colleague Huestis (2009), S(+) isomer of MDMA is responsible for its psychostimulant and empathic effects and the R(-) isomer for its hallucinogenic properties. Uptake, absorption, metabolism and elimination of MDMA in human body MDMA is usually formulated in tablets of its racemate (1:1 mixture of its enantiomers) in doses ranging from 50 to 200 mg (Pizarro et al., 2004), which is most commonly sold in batches of 3–5 for ?10 (Wikipedia, 2009). MDMA powder is also found in the market at a higher price, indicating that it has higher purity. MDMA powder is not usually insufflated (snorted) as it causes sneezing, pain and nosebleeds. MDMA cannot be smoked and is very rarely injected intravenously (AMCD, 2008). MDMA is absorbed into the blood streams and distributed in body. Postmortem analysis by Letter et al. (2002) shows that MDMA is distributed in cardiac muscle, both lungs, liver, both kidneys, spleen, the four brain lobes, cerebellum and brainstem, adipose tissue, serum, vitreous humor, urine, hair and bile upon administration. Rapid distribution of MDMA in body is mainly due to its basic property of pKa around 9.9 and low plasma protein binding, MDMA can diffuse across biological matrices that is more acidic than blood (Pichini, 2005). After an oral administration of MDMA, the plasma concentration peaks in within 1.5 to 2 hours (Cone and Huestis, 2009). MDMA is metabolized by multiple pathways (see Figure 7), primarily involving N-demethylation and O-demethylenation. The enzymes involved in the pathway are a group of cytochrome P450 isoenzymes, including CYP1A2, CYP3A4, and CYP2B6. Firstly, MDMA is O-demethylenated to 3,4-dihydroxymethamphetamine (HHMA) followed by O-methylation to 4-hydroxy-3-methoxymethamphetamine (HMMA). The enzymes involved in the metabolic process are CYP2D6 and catechol-methyltransferase respectively. At a lower rate, MDMA is N-demethylated to 3,4-methylenedioxyamphetamine (MDA) (a reaction regulated by CYP2B6), which is further metabolized to the catechol intermediate (3,4-dihydroxyamphetamine) and finally O-methylated to 4-hydroxy-3-methoxyamphetamine (HMA). In the reactions, the ÃŽ ±-carbon responsible for stereochemical properties of MDMA is not affected and all the metabolites are chiral compounds that may be presented as a mixture of their enantiomers. In addition to these major compounds, some other minor metabolites derived from the activity of monoamine oxidase on the amine residue are also formed (Kolbrich et al., 2008; Pizarro et al., 2004). N-demethylation of MDMA yields 3,4-methylenedioxyamphetamine (MDA), an active metabolite exhibiting similar pharmacological properties as the parent drug. A further O-demethylenation of MDA produces 3,4-dihydroxyamphetamine (HHA) which is mainly regulated by CYP2D6. Additional metabolites are formed by O-methylation of HHMA to 4-hydroxy-3-methoxymethamphetamine (HMMA) and of HHA to 4-hydroxy-3-methoxyamphetamine (HMA), deamination, and conjugation (Cone and Huestis, 2009). The metabolic pathway mainly happens in the liver. Some people with reduced CYP2D6 shows lower metabolic rate of MDMA and thus are more susceptible to MDMA toxicity (ODonohoe et al., 1998; Schwab et al., 1999). Physiological and psychological effects of MDMA Berman et al. (2009), Hensley and Cody (1999) and Piper (2008) reported an increased alertness and euphoria, increased heart rate, blood pressure, respiration and body temperature upon administration of MDMA. United Nation Office on Drugs and Crime (2006) conveys that chronic amphetamines abuse causes agitation, tremors, hypertension, memory loss, hallucinations, psychotic episodes, paranoid delusions, and violent behavior. Withdrawal from high doses of amphetamine-type stimulants (ATS) could result in severe depression. MDMA impairs the temperature control by hypothalamus. This causes MDMA users to die of hyperthermia (Piper, 2008) and some die from hyponatraemia, i.e. the dilution of blood due to excessive fluids taken to counteract heat exhaustion (Parrott et al., 2004). Neurotoxicity of MDMA Nichols (1986) and Vollenweider et al. (1998) categorize MDMA as entactogens, a special class of drug that produce changes in mood, social interactions or feelings of interpersonal closeness and changes in perception. MDMA shares some of the pharmacological effects of stimulants and serotonergic hallucinogens (Cami et al. 2000; Gouzoulis-Mayfrank et al. 1999; Liechti Gamma and Vollenweider, 2001; Tancer and Johanson 2003). MDMA acts an agonists on various neurotransmitters action especially serotonin. Boost in serotonin turnover induced by MDMA tends to generate feelings of contentment, elation, liveliness and intense emotional closeness to others. This causes people to enjoy themselves without their normal concerns and inhibitions. MDMA is classified as neurotoxin. Studies have found evidence for dopaminergic nerve destruction in higher brain regions. As shown in Table 2, the higher brain function such as memory, information processing and storage, complex stimulus analysis and decision making of MDMA users are impaired. CHIRAL DRUG ANALYSIS Chirality Chirality is formally defined as the geometric property of a rigid object (like a molecule or drug) of not being superimposable with its mirror image (McConathy and Owen, 2003). Achiral molecules can be superimposed on their mirror images. Molecules that are not superimposable with their mirror images are said to be chiral. Each chiral molecule will have at least one chirality centre or stereogenic centre (Leffingwell, 2003). Chirality centre of an organic molecule is usually a carbon atom, bonded to four different groups of atoms. Chiral molecules with one chirality centre exist in two enantiomeric forms (see Figure 8). The two mirror images are termed enantiomers. Both molecules of an enantiomer pair have the same chemical formulae and can be drawn the same way in 2 dimensions but in chiral environments such as the receptors and enzymes in the body, they will behave differently. Enantiomers are identical in all physical properties except for their optical activity, or direction in which they rotate plane-polarized light (McMurry, 2004). Some optically active molecules rotate polarized light to the left (levorotatory) while others to the right (dextrorotatory) (Baker, Prior and Coutts, 2002). A racemate (often called a racemic mixture) is a mixture of 1:1 amount of both enantiomers of (+) and (-) enantiomers and is optically inactive. The optical inactivity results from the rotation caused by one enantiomer canceling out that produced by its complementary enantiomer (Beesley and Scott, 1998). The absolute configuration at a chirality center is designated as R or S to unambiguously describe the 3-dim ensional structure of the molecule. R is from the Latin rectus and means to the right or clockwise, and S is from the Latin sinister for to the left or counterclockwise (McConathy and Owen, 2003; Baker, Prior and Coutts, 2002). Pharmacological aspect of chiral drugs In pharmacology, chirality is an important factor in drug efficacy. About 56% of the drugs currently in use are chiral compounds, and about 88% of these chiral synthetic drugs are used therapeutically as racemates (Leffingwell, 2003). As previously mentioned, MDMA is a chiral drug that exists in two enantiomeric forms as shown in Figure 6. Chemical modification at the positions R1 to R9 (refer to Figure 9) of MDMA results in unlimited number of pharmacologically active compounds, some of which are more potent stimulants than others. Although there are several possibilities for side chain modification, substitution on the aromatic ring contributes the most to substantial qualitative differences in pharmacological effects. Hence, it is important to discriminate between the enantiomers present in the drugs administrated as both the enantiomers of a chiral drug may differ significantly in their bioavailability, rate of metabolism, metabolites, excretion, potency and selectivity for receptors, transporters and/or enzymes, and toxicity (McConathy and Owen, 2003). The difference in interaction between a chiral drug and its chiral binding site is illustrated in Figure 10. The different domain of a drug molecule has different binding affinity towards the active site of biochemical molecules in the body. As shown in Figure 10, it is obvious that the active enantiomer has a 3-dimensional structure that allows drug domain A to interact with binding site domain a, B to interact with b, and C to interact with c. In contrast, the inactive enantiomer cannot be aligned to bind the same 3 sites simultaneously. Due to the difference in 3-dimensional structure, binding of the active enantiomer exerts a biological effect, while the inactive enantiomer does not possess any (McConathy and Owen, 2003). The hypothetical interaction of drug enantiomers is supported by the studies done by Matsushima, Nagai and Kamiyama (1998) and Kolbrich et al. (2008) shows that stereoselective cellular transport of MDMA allows the drug to accumulate at different extent in biological matrices. According to ODonohoe et al. (1998) and Schwab et al. (1999), stereoselectivity also affects genetic differences in the expression of metabolic enzymes that are responsible to metabolize MDMA in the body. For example, CYP2D6 is expressed as 2 phenotypes; one being extensive and another as poor metabolizers. Thus, it is obvious that the stereospecificity of a chiral drug can alter absorption, elimination and cellular transport of the drug itself. Analytical aspect of chiral drugs Approximately 50% of marketed drugs are chiral, and of these approximately 50% are racemix mixtures of enantiomers rather than single enantiomers (McConathy and Owen, 2003). Differences in pharmacokinetic and pharmacodynamic activities of the enantiomers of drugs administered as racemates are increasingly appreciated (Porter, 1991). Thus, quantification and qualification of drugs of abuse play important roles in the prediction of and protection from the risk to human health (Nakashima, 2006). Two main approaches to chiral drug analysis have been taken. In the indirect approach, the drug enantiomers are derivatized with an optically pure chiral reagent to form a pair of diastereomers, which may then have sufficiently different physical properties for separation to occur on conventional chromatographic columns (UNODC, 2006; Porter, 1991). In the direct approach, the enantiomers form transient rather than covalent diastereomeric complexes with a chiral selector present either in the mobile or the stationary chromatographic phase (Porter, 1991). Each of these analytical approaches has advantages and disadvantages prevail, depending upon factors such as time, purity, chemical processing, and inherent side reactions (Carvalho et al., 2006). Indirect chiral drug analysis In order to successfully resolve the enantiomers, a stable, optically pure chiral derivatizing reagent (CDR) has to be available for the covalent formation of diastereomeric derivatives (Porter, 1991). Diastereoisomers of amphetamine-type stimulants can be prepared using different reagents such as acylchlorides, alkylsulphonates, isothiocyanates, chloroformates. Moshers acid [R(+) or S(-)-methoxy(trifluoromethyl)phenylacetic acid], Moshers acid chloride, and N-trifluoroacetyl-1-prolyl chloride (TPC, also known as TFAP-Cl) are the most popularly used chiral derivatizing agents (UNODC, 2006). The reaction scheme may be illustrated as follows: The purity of the chiral derivatizing agent is vital in the process of separation of the racemic mixture. The resolution of a racemic drug by the R-enantiomer of a CDR contaminated with its S-enantiomer causes an additional pair of diastereoisomers to be formed, each of which is the enantiomer of one of the first pair (Porter, 1991), as shown in Figure 12. As a result, the enantiomers R-R, S-S and S-R, R-S would coelute in conventional chromatographic systems due to their similar physical properties. Racemization during the reaction would bring about analytical error especially when attempting to quantitate small quantities of one enantiomer in the presence of a large excess of its antipode (Porter, 1991). Methods using chiral derivatization are essentially less expensive and do not require specialized equipment or columns. The use of normal, achiral columns allows easy integration of chiral separations into routine analysis schemes (UNODC, 2006). Thus, considerable flexibility in chromatographic conditions is available to achieve the desired resolution and to eliminate interferences from metabolites and endogenous substances. Moreover, a reasonably good selection of chemically and optically pure CDRs is available for derivatizing various functional groups (Porter, 1991). Direct chiral analysis Chiral gas chromatography (GC), High Performance Liquid Chromatography (HPLC) or Capillary Electrophoresis (CE) are popular methods in direct analysis of illicit drugs (UNODC, 2006). Direct analysis does not require a CDR for covalent diastereomeric complexation. Instead, separation of chiral drugs occurs via the interaction between the enantiomers and a chiral selector. The chiral selector is an optically active compound that may be present in the mobile phase for use with conventional HPLC columns or it may be incorporated into the stationary phase to provide specialized chiral stationary phases (Porter, 1991). Calvalho (2006) lists the most successful chiral packing materials i.e. amylose, Pirkle type stationary phase, cyclodextrin, proteins, and cellulose ester and carbamate derivatives used in GC. Sometimes, derivitization may be carried out with a nonchiral reagent, in order for appropriate molecular interactions with the chiral discriminator to occur and/or to impart requisite spectral or fluorescent properties to the molecule (Porter, 1991). HPLC with fluorescence detection method is done by Al-Dirbashi et al. (1999) in attempt for the determination of methamphetamine in human hair. Nakashima (2006) claimed that the use of a chiral stationary phase in GC to separate pairs of enantiomers after suitable derivatization with an achiral reagent is able to achieve a powerful separation. Recently CE has become a highly competitive tool for chiral analysis of many compounds since it allows for the highly efficient separation of enantiomers without derivatization and specialty columns (capillaries) (Porter, 1991; Ramseier, Caslavska and Thormann, 1999). For the separation of amphetamine-type stimulant using CE, chiral additives such as hydroxyl-propyl beta-cyclodextrin are added in the running buffer. This eliminates the need of derivatization in analysis of chiral drugs commonly used (Iio et al., 2005; Ramseier, Caslavska and Thormann, 1999). Separation of chiral drugs using gas chromatography UNODC (2006), Pirnay, Abraham and Huestis (2006) and Rouen, Dolan and Kimber (2001) agree that gas chromatography/mass spectrometry (GC/MS) is the most common instrumental technique for analysis of amphetamines and derivatives. However, GC/MS still has its limitations. Chiral gas chromatography is selected as the separation technique if the materials are volatile and stable at elevated temperatures. In addition, if the solutes can be derivatized to form a sufficiently volatile product without racemizing the enantiomers, or changing their racemic proportion, then GC may be the choice. GC offers much higher efficiencies, much higher peak capacities and significantly higher sensitivities than LC. It follows, that GC can easily contend with multicomponent mixtures, especially mixtures from biological samples. In addition, the columns have short equilibrium times, trace impurities are easily assayed, and the analyses are shorter providing much faster sample throughput (Beesley and Scott, 1998). Prior to analysis by GC, compounds containing functional groups with active hydrogens such as COOH, OH, NH, and SH have to be derivatized. This is because these compounds tend to form intermolecular hydrogen bonds, hence reducing volatility of the compounds in the machine. They are also thermally unstable and can interact with either fused silica or the stationary phase, causing peak broadening (Danielson, Gallgher and Bao, 2000). Most underivatized amphetamine-type stimulants (ATS) have fragment ions of low m/z ratio, low intensity, and only one fragment ion of higher abundance (base peak). Derivatized ATS usually produces fragment ions of higher m/z ratio and higher abundance. Molecular ions with greater molecular mass have greater diagnostic value, due to the reason that they are not affected by interfering background ions such as column bleed or other contaminants (UNODC, 2006). Capillary electrophoresis as a complementary method in the analysis of MDMA According to Meng et al. (2006), capillary electrophoresis (CE) can be used to complement GC and HPLC methods of amphetamines analysis due to their high efficiency, accuracy, very high resolution, and tolerance to biological matrices. Capillary electrophoresis utilizes the electrical nature of charged molecules and enables the separation of molecules based on charged in an applied electrical field (Landers, 1995). MDMA is an organic compound and so its enantiomers are not charged. Hence, for the separation of enantiomers of MDMA, micellar electrokinetic chromatography (MEKC) is utilized (Beesley and Scott, 1998). This is a modified electrophoresis system in which the chiral selector is added to the electrolyte as additives, or be immobilized on the capillary tube surface as a traditional type of stationary phase (Beesley and Scott, 1998). The applied voltage causes the analytes to migrate through the capillary and being separated (Landers, 1995). Figure 13 shows the instrument used for micellar electrokinetic chromatography (MEKC). As seen in the figure, during sample separation, the individual analytes are driven in the appropriate direction by their inherent electrophoretic mobility (neutral species are static, anionic species move towards the anode, and cationic species move towards the cathode) with a magnitude represented by the arrows. Concurrently, the EOF of buffer towards the cathode, with a magnitude greater than the individual electrophoretic mobilitles, results in electrophoretic zone formation as all analytes (neutral, positive, and negative) are swept past the detector (Landers, 1995). The detector produces an electropherogram that is almost the same as the one obtained from the gas chromatography (see Figure 14). The chiral selector used in micellar electrokinetic chromatography is usually beta cyclodextrin. Cyclodextrin is an oligosaccharide with an external hydrophilic surface and a hydrophobic cavity, in which they can include other compounds by hydrophobic interaction (Tagliaro, Turrina and Smith, 1996). This allow for the separation of molecules with different sizes, charges and polarity. The aim of this literature review is to investigate the effectiveness of GC/MS and CE in the analysis of MDMA enantiomers. Not only that, the enantioselective disposition of MDMA in hair and urine is also reviewed. The use of hair and urine as a medium for drug detection is also explored. CASE STUDY Urine analysis Urine is the most widely used biological specimen for the analysis of illicit drugs (Nakashima, 2006; Rouen, Dolan and Kimber, 2001). According to Ramseier, Caslavska and Thormann (1999), urinary screening of drugs of abuse is usually performed with immunoassay, whereas GC/MS is the standard approach employed for confirmation of the presence and absence of a specific drug or metabolite. The goal of urine drug testing may be stated as the reliable demonstration of the presence, or absence, of specified drugs or metabolites in the specimen (Chiang and Hawks, 1986). Despite a number of persistent shortcomings, such as its susceptibility to tampering, urinalysis is a well-researched technology in which most of the problems have been identified and addressed, if not resolved. It offers an intermediate window of detection making test scheduling an important issue in many situations (Rouen, Dolan and Kimber, 2001). The Physiology of Urine Production Blood is drained through the kidney in the rate of 1.5 litres per minute. Ultrafiltration of blood that occurs at the kidney leads to the production of urine continuously. During urine production the kidneys reabsorb essential substances. Excess water and waste products, such as urea, organic substances and inorganic substances, are eliminated from the body. The daily amount and composition of urine varies widely depending upon many factors such as fluid intake, diet, health, drug effects and environmental conditions. The volume of urine produced by a healthy adult ranges from 1-2 litres in a 24 hour period but normal values outside these limits are frequently reported (Rouen, Dolan and Kimber, 2001; Pichini, 2005). Incorporation of Drugs into Urine The possible ways of drug disposition in the human body is shown in Figure 15. When a drug is smoked or injected, absorption is nearly instant and excretion in urine begins almost immediately. According to Pichini (2005), 80% of the drug is metabolized by the liver, leaving 20% of the drug to be excreted unaltered. However, absorption is slower when a drug is orally administered and excretion may be delayed for several hours. Generally, a urine specimen will contain the highest concentration of parent drug and metabolite within 6 hours of administration. As for MDMA, the peak concentration is reached after 2 hours of administration (Cone and Huestis, 2009). As drug elimination usually occurs at an exponential rate, for most illicit drugs a dose will be eliminated almost completely within 48 hours. A number of factors influence the detection times of drugs in urine including the quantity of drug administered, parent drug and its metabolite half-life, cut-off level used, and a number of physiological factors. Fallon et al. (1999) reported that the plasma half-life in humans of (R)-MDMA (5.8  ± 2.2 h) was significantly longer than that of (S)-MDMA (3.6  ± 0.9 h). It is also noted that for many of drugs, frequent, multiple dosing over extended periods of time can cause the drug to accumulate in the body resulting in significantly extended detection times, and leads to the possibility of hair analysis which will be discussed in the later part. The detection times in urine are significantly greater than the detection times in blood because most drugs are rapidly eliminated from blood both by the bodys metabolic system and by excretion into urine (DuPont and Baumgartner, 1995). As the bladder is emptied only a few times during the day, the urine becomes a reservoir of drugs and metabolites (AIC Research and Public Policy, 2003). According to DuPont and Baumgartner (1995), most abused drugs, including their metabolites, fall to low levels in the blood within a few hours of last drug use and so urine samples generally have a short surveillance window (SW) of about l-3 days (see Table 3). AIC Research (2003) also reported that longer detection time of drugs is due to high doses and high urine pH. Despite of its small detection time, urine testing is still a reliable and convenient way of investigating whether a person has abused drugs in the past few days. The comparison between commonly used specimens for drug analysis is shown in Table 3. Case Study One: Stereochemical Analysis Of 3,4-Methylenedioxymethamphetamine And Its Main Metabolites In Human Samples Including The Catechol-Type Metabolite (3,4-Dihydroxymethamphetamine) Objectives This case study aims to determine the enantioselective disposition of MDMA and its major metabolites, 3,4-methylenedioxyamphetamine (MDA), 3,4-dihydroxymethamphetamine (HHMA) and 4-hydroxy-3-methoxymethamphetamine (HMMA) in human urine. The R versus S enantiomer of MDMA and its metabolites in urine samples after administration of known amount of MDMA is also calculated. Other than that, the use of indirect method in determining concentration of MDMA and its metabolites by chemical derivatization is also illustrated. Results and Discussion Urine samples were obtained from seven healthy recreational users of MDMA. They were given a single 100-mg oral dose of (R,S)-MDMA ·HCl (Pizarro et al., 2004). Participants were phenotyped with dextromethorphan for CYP2D6 enzyme activity and all were categorized as extensive metabolizers (Schmid et al., 1985). Urine samples were collected before and after drug administration at 0 to 2, 2 to 6, 6 to 12, 12 to 24, 24 to 48 and 48 to 72 hour time periods, acidified with HCl, and stored at around 20 °C until analysis (Pizarro et al., 2004). The samples and standard solutions were analyzed by GC/MS using achiral column with 5% phenyl 95% dimethylpolysiloxane cross link (15 m Ãâ€" 0.25 mm Ãâ€" 0.25  µm film thickness) before and after a chiral derivatization. MDMA in the urine sample was derivatized using (R)-(-)-ÃŽ ±-methoxy-ÃŽ ±-trifluoromethylphenylacetyl chloride (Figure 16) in ethyl acetate/hexane (50:50) that contained 0.015% triethylamine as described by Pizarro et al. (2003). Derivatization step functions to induce volatility to the sample for GC analysis (Beesley and Scott, 1998). A baseline enantiomeric separation was obtained for all the studied compounds in a single run. Chiral analysis of plasma and urine samples was carried out by combining the extraction procedure developed for the high performance liquid chromatography analysis method for HHMA quantification (Segura et al., 2002) and derivatization steps developed for GC/MS determination of enantiomers of MDMA, MDA, HMMA, and HMA (Pizarro et al., 2003). Extraction and derivatization coupling was not achieved easily because chemical properties of extracted samples make it impossible for the target compounds to be derivatized. The presence of considerable amounts of HCl in t he elution mixture was responsible for the formation of the corresponding amine chlorhydrate salts making amine reaction unfeasible. An attempt using evaporation of extracts to eliminate HCl be

Unmasking Monsters of Meaning in the ‘Narrative Complexity’ of Supernat

The subjects of this study, The X-Files (Carter, 1993-2002) and Supernatural (Kripke, 2005-), can be seen as innovative pioneers of ‘Narrative Complexity’ and of the ‘monster-of-the-week’ concept. The X-Files stars FBI agents, Mulder and Scully, as they take charge in investigating the X files (cases that occur through unknown phenomena). Mulder, the believer, and Scully, the sceptic, face corrupt government officials, monstrous mutants and phenomena that cannot be explained. The episodic and formulaic series allow Mulder and Scully to face phenomena after phenomena while being spliced with a greater ‘mytharc’ concerning government corruption and of the alien colonisation of earth. Supernatural stars Dean and Sam Winchester, brothers in arms, who also, within formulaic and self-contained episodes, hunt monsters and creatures of folklore, urban legend and myth. Supernatural features arcs every season that take Dean and Sam searching for their los t father, preventing a demon apocalypse and do battle with Satan and God’s Angels. American television has, since its very first broadcast, twisted and changed to cater towards its ever-growing and ever-changing audience (Mittel, 2007, p.162-163). Narratives, structure styles, special effects, characters and themes have developed and changed, been tested and tried. Mittel identifies the three notable structures of the television: the anthology, the serial and the series (2007, p. 163). For this study, we are more interested in the serial and the series for its crossover in narrative complexity. Mittel states that ‘narrative television offers ongoing storyworlds, presenting specific opportunities and limitations for creating compelling narratives’ (2007, p.163). The ‘episodic series’ is bro... ...d Everyday Life in Buffy the Vampire Slayer. In: M. Hammond and L, Mazdon, eds. 2005. The Contemporary Television Series. Edinburgh: Edinburg University Press, pp.159-182. Hodges, L., 2008. Mainstreaming Marginality: Genre, Hybridity, and Postmodernism in The X-Files. In: J. P. Tellote, ed. 2008. The Essential Science Fiction Television Reader. Kentucky: Kentucky University Press, pp.231-246. Mittel, J., 2007. Film and Television Narrative. In: D. Herman, ed. 2007. The Cambridge Companion to Narrative. Cambridge: Cambridge University Press, pp.156-171. Mittell, J., 2006. Narrative Complexity in Contemporary American Television. The Velvet Light Trap, 58(32), pp.29-40 Nixon, N., 1998. Making Monsters, or Serializing Killers. In: R. Martin and E, Savoy, eds. 1998. American Gothic: New Interventions in a National Narrative. Iowa: Iowa University Press, pp.217-236.

Ufc Business Strategy

General Environment The fastest growing sports organization in the world, the Ultimate Fighting Championship (UFC), started in 1993 as a professional mix martial arts (MMA) organization. Once the UFC brand was launched, MMA popularity surged in Brazil, followed by immense interest in Japan where these bouts became major events. The most recent fight in April, UFC sold 55,000 tickets in minutes, became the largest paid audience in North American to witness a mix martial arts event.They delivered top rating in male 18-34 and 18-49 demographics. Globally, UFC programming is broadcast in over 149 countries and territories, reaching a half a billion homes worldwide, in 20 different languages. Response to the UFC brand of MMA has been tremendous, resulting in a growing fan base that has grown exponentially through the years. So, UFC is very popular to the whole world. Porter’s Five Forces: Threat of New Entrants Threat of new entrants is low because everyone in the world is watching UFC.UFC is the only mixed martial arts industry in the world, but it is part of fighting sports industry. Power of Suppliers I would say that power of suppliers is high because the whole world is selling UFC’s stuffs. Suppliers are selling UFC apparels, shorts, DVDs, equipments and gears. Some of the suppliers including Affliction are selling UFC’s apparel. Others (Clear Vision) are selling DVD such as work-out or copies of UFC fights. UFC spends a lot on advertisement because they’re one of the most recognizable by the whole world.The Ultimate Fighting Championship has partnered with Fox  for a seven-year broadcast deal through the  Fox Sports  subsidiary, effectively ending the UFC's  Spike TV  and Versus (now  NBC Sports Network) partnership. I believe fighters are one of the suppliers because they are paid per fight, with amounts depending on how well-known the fighters are and how well sponsored a fighter and an event is. Fighters will typicall y get paid money to fight with an additional bonus if they win. Power of Buyers Buyers’ power is really high because UFC is very popular to the world.The UFC brand completely restructured MMA into a highly organized and controlled compact sports. Now, UFC produces over twelve live Pay-Per-View events annually that are distributed residentially through North American cable and satellite providers including iNDEMAND Networks, DIRECTv, DISH Network, TVN Entertainment, Shaw Pay-Per-View, BellTv, Viewers Choice, SaskTel Max and via the Internet worldwide on UFC. com and Yahoo! , commercially through Joe Hand Promotions. It is very expensive because you have to order Pay-Per-View or DIRECTv to watch UFC.Substitute I don’t believe there is a substitute because UFC is wrestling, martial art mixed. UFC is a very unique sport, but it is part of fighting sports. So, I believe substitute is very low. There are wrestling, boxing, martial arts mixed, and other fighting sports. Compe titor Analysis: Boxing Boxing is a  martial art  and  combat sport  in which two people engage in a contest of strength, reflexes, and endurance by throwing  punches  at an opponent with  gloved hands. They can get two most popular, best and recognizable boxers to fight each other.They have so many passionate fans. They’ve partnered with HBO and SHOWTIME. They are focused on the best fighters from all over the world and give the best show for the world. Internal Industry: Strength UFC is one of the most popular sports, not in just United States, but in the whole world. They have surpassed the boxing on fans’ popularity. They are really high on suppliers’ and buyers’ power. They have sold out their tickets within minutes, not hours or days. Weakness It is not for younger kids to watch UFC because it is a bad image and bad influence for them.You don’t want to have bullies at schools. UFC are worrying about what the fighters say or do be cause Advocacy groups have criticized the fighters’ comments as sexist and homophobic. The incidents cited by National Center on Domestic and Sexual Violence include an undated video linked on unfitforchildren. org, in which UFC fighter Quinton â€Å"Rampage† Jackson  urges a Japanese-speaking fan to say nasty words. Also, people are complained about their advertisement because they showed a half nude woman in one of their commercial with Bud Light Lime. Recommendation

ENGLISH ESSAY WRITING SERVICES

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Free Essays on Cyber Law

Cyber Law Computers and technology have begun to challenge our nation’s law makers. Chad Crumley, a 16 year old from Brandon, is one such example. Chad’s interest in computers led him to hours of hacking and experimentation. Being young, Chad intended only to play jokes on his friends. Chad had used his father’s computer to send a small virus to a few of his internet friends. Unfortunately for Chad, his father used the same computer to communicate with the six corporations which he supplied software for. Chad’s virus made its way into most of the companies and caused a total of $700,000 dollars in damage. The court now faces the difficult task of applying the constitution to a new field. It would make more sense for this case to be handled in civil court as opposed to criminal charges being filed. A criminal case would be weak considering there was no criminal intent and the fact that Chad is a juvenile. On the other hand a civil case would also be a difficult pursuit. Unless Chad’s parents are incredibly wealthy, it would be difficult for the companies to recover both damages and lawyer fees especially in a trial where Chad could possibly be found innocent. Chad’s accidental infection of the corporate computers would exempt him from having any criminal liability (mens rea). In a civil case, the most effective (though still not strong) approach would be to argue that both Chad and his parents violated duties of care. First Chad’s parents are responsible for him as he is still a juvenile. Proper monitoring of Chad’s computer use may have avoided some damage. Second, Chad’s father had a duty to the businesses he worked with to protect their interests. But both would most likely be thrown out due to foreseeabiliy. The results of Chad’s actions were not the typical result of a 16 year olds actions on the computer; and therefore, not foreseeable by either Chad nor his parents and would be proven... Free Essays on Cyber Law Free Essays on Cyber Law Cyber Law Computers and technology have begun to challenge our nation’s law makers. Chad Crumley, a 16 year old from Brandon, is one such example. Chad’s interest in computers led him to hours of hacking and experimentation. Being young, Chad intended only to play jokes on his friends. Chad had used his father’s computer to send a small virus to a few of his internet friends. Unfortunately for Chad, his father used the same computer to communicate with the six corporations which he supplied software for. Chad’s virus made its way into most of the companies and caused a total of $700,000 dollars in damage. The court now faces the difficult task of applying the constitution to a new field. It would make more sense for this case to be handled in civil court as opposed to criminal charges being filed. A criminal case would be weak considering there was no criminal intent and the fact that Chad is a juvenile. On the other hand a civil case would also be a difficult pursuit. Unless Chad’s parents are incredibly wealthy, it would be difficult for the companies to recover both damages and lawyer fees especially in a trial where Chad could possibly be found innocent. Chad’s accidental infection of the corporate computers would exempt him from having any criminal liability (mens rea). In a civil case, the most effective (though still not strong) approach would be to argue that both Chad and his parents violated duties of care. First Chad’s parents are responsible for him as he is still a juvenile. Proper monitoring of Chad’s computer use may have avoided some damage. Second, Chad’s father had a duty to the businesses he worked with to protect their interests. But both would most likely be thrown out due to foreseeabiliy. The results of Chad’s actions were not the typical result of a 16 year olds actions on the computer; and therefore, not foreseeable by either Chad nor his parents and would be proven...

A Report on Oil Production in Libya and Operational Policies with Global Societal Impacts

A Report on Oil Production in Libya and Operational Policies with Global Societal Impacts Background The hydrocarbon industry forms the back bone of the Libyan economy. It is estimated by the IMF that contributed to about 95% of export earnings in Libya in 2010 (Country Analysis Briefs, 2011). The oil and gas journal (OGJ) has approximated Libya’s oil reserves to be about 46.4 billion barrels, the largest in the African continent.Advertising We will write a custom report sample on A Report on Oil Production in Libya and Operational Policies with Global Societal Impacts specifically for you for only $16.05 $11/page Learn More In 2010, it is estimated that the total oil production was about 1.8 million barrels per day. A majority of the oil in Libya (about 80%) is in Sirte basin. 25% of total oil production is from Murzuq basin and the remaining largely comes from Pelagian Shelf Basin (Country Analysis Briefs, 2011). Sector Organization The Oil industry is run by state owned National Oil Corporation (NOC) which implements Exploration and Pro duction Sharing Agreements (EPSA) with international oil companies (IOC’s) such as Total, Repsol YPF, Statoil Hydro, Occidental, OMV, ConocoPhillips, Hess, Marathon, Shell, BP and Exxon Mobil. NOC also engages in field development and downstream activities (Country Analysis Briefs, 2011). Production and refining Libya’s oil production has been on the decline despite hitting 3 million barrels per day (bbI/d) in 1960’s. Despite the decline, crude oil has increased from 1.4 million bbl/d in 2000 to 1.8 million bbl/d in 2010. There are about 5 refineries with a total capacity of 378000 bbI/d. These include Ras Lanuf-crude oil capacity of 220,000 bbl/d; Az Zawiya -120,000 bbl/d; Tobruk -20,000 bbl/d; Sarir, 10,000 bbl/d; and Brega 8,000 bbl/d (Country Analysis Briefs, 2011).. Challenges Facing Oil Production Civil war and a decade of the United States and international sanctions have affected oil industry.These include sanctions by the United States and the United N ations in 2003 and 2004. Since sanctionS were lifted, Libya has been the target of international oil companies which boosted oil production even despite uncertainties in terms of regulations and renewal of contracts. However, government plans to increase oil production were slapped by the US’s designation of Libya as a state sponsor of terrorist activities in 2006 and the civil war (Country Analysis Briefs, 2011).Advertising Looking for report on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More Operational Polices With Global Societal Impacts Oil companies in Libya are usually locally or globally subjected to operational policies which have global societal impacts. Such policies are geared towards environmental protection (Wawryk, 2010). For example IOC’s operating in Libya that are members of other bodies and are subjected to laws and best practices to improve health, safety and environment globall y. On a global perspective, the International Association of Oil and Gas Producers (OGP) have guidelines and standards with a global societal impact. Other operational policies may include those of NGOs, IGOs, World Conservation Union, (UNEP), World Bank and the international chamber of Commerce (Wawryk, 2010). Operational policies tend to address vulnerability to disruption and higher prices and the effects can be long-term. This is because material shifts in the energy sector takes time either through efficiency, renewable or increased oil and gas production. Policy options which are short-term (unlike wider national security and diplomatic issues) are limited. Oil exporters like Libya with alternative production capacity are bound to take short-term decisions in an attempt to moderate prices through product-level-adjustments, but this ability is determined by internal decisions (Country Analysis Briefs, 2011). Other operational policies with global impacts are from within the Lib yan government. For example participation of IOC’s in oil concessions was previously at 49% which was reduced due to changes in oil production and sharing agreements under EPSA. The IOCs were under obligation to rewrite contracts in an attempt to comply NOC’s demands. This created uncertainty in the contractual arena and reduced oil exploration, despite the global need for oil (Country Analysis Briefs, 2011). References Country Analysis Briefs, (2011). Energy information administration. Retrieved from https://www.eia.gov/beta/international/analysis_includes/countries_long/Libya/libya.pdfAdvertising We will write a custom report sample on A Report on Oil Production in Libya and Operational Policies with Global Societal Impacts specifically for you for only $16.05 $11/page Learn More Wawryk, A. (2010). International environmental standards in the oil industry: improving the operations of transnational oil companies in emerging economies. Univers ity of Adelaide: University of Adelaide Press.

Oxygenation in Paediatrics Essay Example | Topics and Well Written Essays - 500 words

Oxygenation in Paediatrics - Essay Example This is a simple visual inspection and involves checking for signs of reducing cyanosis on the tongue and extremities such as the palms and soles of the feet. This method is simple and easy to implement. However, differences in skin color and inability of the health professional to discern color change significantly limit this method. For instance, in blacks, cyanosis cannot be easily observed and may sometimes go unnoticed until it is too late. To solve this limitation, equipment are usually used. The most common of the instruments is the pulse oximeter. This is a device that is attached to the patient’s finger and measures the actual oxygen content in the blood. It, therefore, monitors the extent and effectiveness of oxygenation (Sinha 2012, p. 312). The main limitation of the equipment monitoring is that some people may read and interpret the readings wrongly leading to undue panic or preventing timely action. In addition, the connection of the equipment may vary the readin gs. There are various methods of oxygen administration in infants. These methods are selected depending on the availability of the equipment and hence affordability, as well as preference and infants condition. The methods are divided into invasive and non-invasive methods. The invasive methods make use of a tracheal tube and are recommended for infants with severe breathing conditions. The non-invasive methods include headbox oxygen administration which measures the oxygen concentration before entry into the respiratory system. Other methods include facemasks that assist in concentrating the oxygen being delivered around the nose. Both the headbox and facemasks pose a danger of carbon dioxide accumulation with increased expiration. Nasal prongs, nasal catheters and the nasopharyngeal catheters are also used to deliver oxygen to the lower

World War I Essay Example | Topics and Well Written Essays - 1000 words - 1

World War I - Essay Example The first one was between Germany and Austria-Hungary, known as the Dual Alliance. It was followed by the Austro-Serbian Alliance of 1881. Similarly, there was the triple alliance of 1882, the triple entente and Anglo-Russian Entente of 1907, and Entente Cordiale between France and Britain (Tucker 4). Thus, it was impossible for any of these nations to stay away from war if any of their allies declared war. The next important reason was imperialism. The term imperialism means one country taking over another land or territory and imposing its own rule in the new land. The beginning of twentieth century saw the spread of British Empire into all continents. Similarly, France had considerable control over much of Africa. As industrialization set in, countries started aggressively looking for more markets to sell their products. As Germany entered the competition, there was increased rivalry and enmity. In addition, increased militarism also had its role. The term militarism means the inc reased importance given to military by governments. In fact, as a result of the European divide, nations were aggressively engaged in arms race. To illustrate, both France and Germany considerably increased their military size and rivalry rose over sea turf. In order to retain their dominance at sea, Britain introduced their battleship called ‘Dreadnought’. Germans followed suit by introducing their own battleships. In addition, Germany even prepared a plan to attack France through Belgium in case Russia attacked them. Thus, militarism played its role in starting World War I. Another important reason was the rising nationalism. Some examples of this rising feeling were the re-unification of Italy and Germany. While France was angry at the loss of territory to Germany, many areas of Serbia and Austria-Hungary were disturbed by different nationalist groups. In fact, the US was engaged in trade with most of the nations involved in the world war. However, there was higher t rade with Britain and France. Thus, at that time, the US had huge economic investment with both these nations. If they lost the war, they would not be able to pay back the debt, which meant a collapse of the US economy. Secondly, both the nations were purchasing arms from US on credit. So, it was necessary for the US to see that the nations were able to pay for it. Moreover, President wanted to make the world open to democracy. Thus, there arose the general idea that France and Britain were fighting against a threat to democracy. However, one of the most important reasons is the German use of submarine warfare and the sinking of the ship Lusitania killing more than hundred Americans. Furthermore, a telegram from the German foreign secretary to the German Ambassador to Mexico was intercepted, translated and sent to America by the British. The telegraph was meant to create an alliance between Germany and Mexico. Under Title 1, section 3 of the Espionage Act, one who makes false report s or false statements could be given even twenty years imprisonment if it was found that the same was done to interfere with the operation of the military. Secondly, under title 12, postmaster general got the legal power to declare a material as un-mailable if it urged treason, or forcible resistance of the law. That means freedom of speech was seriously hampered by this. Another very serious issue was the power given to the president to censor publication of material if found harmful for the nation or useful to the enemy. It all meant that right to speech was impaired by the act. The Seditions Act added a large number of more actions in the prohibited list. It was claimed that ‘

Euonymus alata - Essay Example | Topics and Well Written Essays - 750 words

Euonymus alata - - Essay Example long and have tapering tips. During the Autumn season the leaves of this plant turn a bright reddish color. It is also called the â€Å"winged euonymus† because most of these cultivars possess two t three corky flanges or wings that are present along the length of the branches. The branches which are lime green in color when the plant is young become ash gray as the plant grows older. The flowers are small and grow in Axillary pairs on ‘Y’ shaped stems. The flowering season for the Euonymus alata takes place between the months of late April to June. By September or October the flowers mature and turn into reddish – purple fruits that have four seeds inside. These seeds are dispersed by birds and also gravity. The Euonymus alata is an exceedingly tolerant plant and can withstand a lot of sunlight and thrives in poor soil conditions. Therefore this plant becomes quite a threat to grow in open environments. Seeds could be stored up to long periods and made use of much later as it possesses good longevity. For healthy growth the Euonymus alata could be treated with an application of herbicide. The Euonymus alata is also called the â€Å"burning bush† which is deciduous and grows to a height of about 20 ft. It thrives greatly throughout eastern United States and is a highly invasive plant. This plant is a native of Northeastern Asia and for the first time it was introduced to North Americans in the 1860’s for the purpose of using it as an ornamental plant. The leaves which are dark green in color are rounded, smooth and taper at the tips. This winged burning bush invades forests and also a wide variety of other habitats, fields, roadsides and side- walks. Once these plants are strongly established, they grow wildly and form dense thickets, covering the other plants and displacing other native flora in the area. Invasive plants grow at a much quicker rate and aggressively, spreading wildly and displacing other fauna in the same area around

What impact did the Atlantic slave trade have on the nations of the Essay

What impact did the Atlantic slave trade have on the nations of the West African interior - Essay Example As the slave traders only left the old and the young behind, with the young and able bodied Africans all captured to be sold later, therefore it was very hard for those who were left behind to revive the economy and make a living for themselves, resulting, often, in starvation and more deaths. Those who were captured were transported by forced marches across the continent, further causing deaths. Moreover, not all who were captured were transported to other continents, which resulted in their displacement within the continent, which caused adverse affects to the region they were left in. There was massive relocation on the part of many communities, as they did not want to be within short distance of the slave traders’ route, which caused them to lose all advancements they had made in their present areas. Not only that, as these communities were more focused on saving themselves and trying to hide from the slave traders, they had little or no economic and technological development. As the Europeans were involved completely in the slave trade, they did not want the African states to centralize due to the adverse affects of this centralization to the slave trade. Due to this reason, the European powers did not allow much political progress to be made in the region. This also resulted in despotic rulers or elders, often if not always funded by Europeans, being placed over the people, who did not allow much interaction between the states, and who often, suppressed their own people and allowed the slave trade to go on. All of this caused the continent to be pushed back in time with little or no progress being made at any level. The African people were often disorganized with the whole continent lagging far behind in its economic, political and social growth. The slave trade was the first step, therefore one can say, in leaving the doors open for European colonialism in the African continent, which was a further cause for the problems of the

Strategic Management Essay Example | Topics and Well Written Essays - 1000 words - 6

Strategic Management - Essay Example Primark has been a retailing giant in the fashion industry that has over a few years been successful. Some of its strategies have over the years included effective marketing to specific targets across Europe. Primark’s target market is mostly the fashion sensitive age group which is basically people with the age below thirty five years of age. They also deal mostly with brand names that are minor, which translates to cheap quality fashionable trends. They have maintained their market by providing the same product of the same quality at a lower price than their competitor provide. This accompanied with the effective management of response and delivery mechanisms has ensured that Primark has maintained its competitive and reliability position in the European market. Their computerised warehouse controls and an effective efficient distribution networks has made sure that Primark stays top notch in customer satisfaction. With the current technological capability, social life has b een incorporated with the business aspect of running things. Companies have been compelled to adapt social media and the use of the internet to provide their services. Marketing and advertising have been forced to tap into the high usage of internet to make a large profit. With just under three billion people using the internet and over two billion people using smart phones, companies have resolved to a paradigm shifts. Some retail and distributing stores have moved from slightly depending on the internet to full dependence of the internet for all their services. Companies like Amazon and eBay who are also giant retailers have completely depended on online shoppers successfully for their sales. Primark has been reluctant to adapt to this marketing and sales strategies but has just kept the traditional walk in stores. This habit is however facing a challenge as more people change their shopping habit coupled with the various technological products that arise in the market. With Prima rk’s main target being people who are below thirty-five years of age, they are bound to adjust and shift into providing online shopping solutions for their clients. This is because it is estimated that the highest number of internet users are people who are below the age of thirty five years. This brings Primark head to head in confrontation and demand from its customers. With the global penetration of internet use, coupled with the increase in the use of mobile devices especially smart phones also creates the necessity to Primark of adoption an online shop. The demand in the usage of these solutions provides a huge market in the retail sector. Another factor that might make it inevitable for Primark to adopt the online retail shop is the use of social media marketing and internet marketing. Over one, half of Europe’s population has one or two active social media accounts. The usage of mobile phones and tablets has been very addictive and convenient at the same time. A large number of people rarely get the time to walk around, let alone spend time with their families. Online jobs and jobs that demand regular travelling or jobs which have squeezed time schedules create least chances for shopping to the affected people. This drives away all the interested clients that might have purchased the said products. Providing such clients with an alternative shopping model enables them to purchase the products online at any time. This not only stops the retailer from losing

Ebay Strategy Essay Example | Topics and Well Written Essays - 750 words

Ebay Strategy - Essay Example As the report declares eBay operates the leading online auction community on the Internet. Secondly , the second strength is intellectual property .eBay’s intellectual property such as its trademarks, copyrights, patents and domain names will help to give the company a competitive advantage over its rivals in the market place. Then , Brand is one of the key strengths of eBay.The strength of the eBay brand name is increasing. The brand is now becoming more mainstream, as it benefits from an increase in both brand awareness and brand recognition. In addition , Double-digit growth in sales has been seen in a number of the company’s eight core product categories. Pay Pal is one of the most successful strategies for eBay.The acquisition of Pay Pal has helped the company to enhance the experience of customers using eBay.This has had a knock on effect and helped to boost the satisfaction of customers using eBay. Perhaps one of eBay’s biggest strengths is its business mo del. The company’s business model means that eBay has no inventory and low capital requirements. This paper stresses that there are also some weaknesses of eBay strategy .The first is advertising revenues. Although advertising revenue only represents a small proportion of revenues, it is an area where eBay should be looking to exploit in order to generate greater revenues for the company as a whole. The second one is technology development. eBay still needs to improve a number of areas of its website in order to generate increased sales in the future.

What impact did the Atlantic slave trade have on the nations of the Essay

What impact did the Atlantic slave trade have on the nations of the West African interior - Essay Example As the slave traders only left the old and the young behind, with the young and able bodied Africans all captured to be sold later, therefore it was very hard for those who were left behind to revive the economy and make a living for themselves, resulting, often, in starvation and more deaths. Those who were captured were transported by forced marches across the continent, further causing deaths. Moreover, not all who were captured were transported to other continents, which resulted in their displacement within the continent, which caused adverse affects to the region they were left in. There was massive relocation on the part of many communities, as they did not want to be within short distance of the slave traders’ route, which caused them to lose all advancements they had made in their present areas. Not only that, as these communities were more focused on saving themselves and trying to hide from the slave traders, they had little or no economic and technological development. As the Europeans were involved completely in the slave trade, they did not want the African states to centralize due to the adverse affects of this centralization to the slave trade. Due to this reason, the European powers did not allow much political progress to be made in the region. This also resulted in despotic rulers or elders, often if not always funded by Europeans, being placed over the people, who did not allow much interaction between the states, and who often, suppressed their own people and allowed the slave trade to go on. All of this caused the continent to be pushed back in time with little or no progress being made at any level. The African people were often disorganized with the whole continent lagging far behind in its economic, political and social growth. The slave trade was the first step, therefore one can say, in leaving the doors open for European colonialism in the African continent, which was a further cause for the problems of the

Ebay Strategy Essay Example | Topics and Well Written Essays - 750 words

Ebay Strategy - Essay Example As the report declares eBay operates the leading online auction community on the Internet. Secondly , the second strength is intellectual property .eBay’s intellectual property such as its trademarks, copyrights, patents and domain names will help to give the company a competitive advantage over its rivals in the market place. Then , Brand is one of the key strengths of eBay.The strength of the eBay brand name is increasing. The brand is now becoming more mainstream, as it benefits from an increase in both brand awareness and brand recognition. In addition , Double-digit growth in sales has been seen in a number of the company’s eight core product categories. Pay Pal is one of the most successful strategies for eBay.The acquisition of Pay Pal has helped the company to enhance the experience of customers using eBay.This has had a knock on effect and helped to boost the satisfaction of customers using eBay. Perhaps one of eBay’s biggest strengths is its business mo del. The company’s business model means that eBay has no inventory and low capital requirements. This paper stresses that there are also some weaknesses of eBay strategy .The first is advertising revenues. Although advertising revenue only represents a small proportion of revenues, it is an area where eBay should be looking to exploit in order to generate greater revenues for the company as a whole. The second one is technology development. eBay still needs to improve a number of areas of its website in order to generate increased sales in the future.

The imaginative landscape Essay Example for Free

The imaginative landscape Essay It is human nature to long to belong, to fit neatly and comfortably into a familiar niche. It allows for a foundation, on which to build upon. It often nurtures us, but sometimes, as our ever static identities develop, we surpass it. We out grow it. It is when we are sheltered and content, that the prospect of leaving or letting go is most difficult, as we must uproot ourselves. In order to keep our roots, which are so deeply buried in our foundation, we simulate our previous, traditional landscapes, in order to keep them alive. Through language, tradition and others, we can partially re-create traditional landscapes. As immigrants of the same nationally huddle together in a suburb-an island of familiarity in a sea of strangeness- in the hope that it might be something like is was before. Some wish to keep their cultures and traditions sacred and unaltered by treasuringthe recent past, simultaneously blinding themselves from being open to new traditions; as in the case of Old James. This leaves him to feel isolated, having no place to re establish his roots, stifling further growth. Old James is malcontented that Young James, disparate from his family, will not settle his roots in Ettrick Valley; go[ing] on and not remember[ing] a thing of Scotland. Young James, and those who follow him will have not emotional affiliation with Scotland, simply, knowing that it is the place of his ancestors orirgons. Like many others, tradition and culture of those gone before is lost, only to forge new ones, and a new foundation and a different sense of belonging.

The role of teaching assistants

The role of teaching assistants This essay will discuss the different roles of teaching assistants in primary schools, through first hand observation and also by way of other resources such as government guidelines and journal articles. Teaching assistants (TAs) were originally given the title of non-teaching assistants, however, the non was dropped when it became clear that teaching assistant provided valuable input into the everyday workings of the classroom. TAs were introduced in an attempt to reduce the workload of teachers which would in turn raise the standards of the classroom in which the work (DfES, 2000). Between 1999-2001 the government injected considerable funds into Local Education Authorities to enable them to employ and train around 20,000 new teaching assistants (Ofsted, 2002). The DfES (2003) states that teaching assistants are providing effective and valuable support in a wide range of settings and envisages an enhanced role for teaching assistants to free teachers from non related tasks. My observations seem to mirror the governments guidelines and proposals for utilizing TAs to reduce the workload of teachers. From my observations of teaching assistants in the classroom, I have found that they have many roles and responsibilities. I have also observed that different teaching assistants have different roles. For example: the main TA for the class has duties varying from gathering resources and taking photographs, to playground duties and helping small groups of children stay on task in the classroom. This particular TA also has the responsibility of teaching small groups of children for Rocket Reading. In rocket reading, children gather from different classes and are grouped by ability rather than age. The TA has the responsibility of teaching the key sounds and words for their level. There is also a floating teaching assistant who moves between classes, as and when she is needed. This TA appears to mainly focus on tasks which do not involve the children such as photocopying resources and making up the display boards. However there is research that suggests, if not used effectively, that TAs could possibly have a detrimental effect (albeit inadvertently) on the educational and social wellbeing of some pupils, particularly those who have special educational needs. Children with special educational needs often have a TA who works almost exclusively with them. There is research which suggests that excessive proximity of teaching assistants could lead to things such as behavioural problems and social isolation as the child becomes to dependant on the TA (Giangreco Doyle, 2007). I have observed rare occasions when the teaching assistant has had responsibility for the whole class. However, this is only for very short amounts of time and usually during transition times for example, between the end of lunchtime play and the start of the afternoon session. I have not seen any evidence that the TAs are expected to do any whole class teaching. In the absence of the class teacher, a supply teacher is used rather than giving the responsibility to the teaching assistants. This may be due to the lack of adequate training of the TAs or the preference of the head teacher, unfortunately I have not, as yet had the opportunity to find out this information. However, the Secretary of State has suggested that the role of teaching assistants could be expanded to include supervising classes undertaking work set by the class teacher, administering tests and covering teacher absence (Ofsted, 2002). Cajkler Suschitzky ( 2007) suggest that TAs should be quite deeply invloved in the everday workings of the classroom. This should include knowing about the curriculum, schemes of work, policy and lesson planning. However, from my observations, the TAs do not have any input into what is taught or how but just follow instructions given by the teacher. These are usually things such as keeping children on task rather than giving any indepth help on the lesson being covered. The TAs often have to refer back to the teacher when asked a question by a child. The TAs do seem to be expected to know the curriculum in any depth, schemes of work or policy. These things do not appear to be relevant to the tasks which are expected of them. The only task in which i have seen the TAs using and needing any indepth knowledge is in the rocket reading exercises. Some of the TAs in the school have had training in this area and therefore have the extra knowledge which is used to the advantage of the rest of the teaching staff and also benefits the children as they can be taught in much smaller groups. Many reports and studies show that the use of teaching assistants in the classroom benefit the teacher as well as the children. However, a report by the Institute of Education suggests that less progress is made by children who have the support of a TA than those of a similar age and ability who do not receive the same level of assistance. The report claims that the more support they recieve the fewer gains they make. The findings are based on two main problems that are interlinked. It is claimed that teaching assistants are often assigned to the children in most need of educational help. However, this means that the child has less time with a qualified teacher , therefore reducing the amount of actual teaching they receive (Times, 2008). From my observations i would somewhat agree with these findings. One child in the class has recently oined the class after arriving from Poland.he receives extremly little support, guidence or teaching fom the class teacher.his day is spent either with a non speaking TA or working independently. However he is lucky enough to have another six year old in the class who is also Polish but speaks very good english who translates for him. In conclusion, i feel that that TAs are an extremely important part of the dailybrunning of the classroom. The main roles in which they are involved in allows the teacher to concentrate on actually teaching the class rather than concentrating on what could be seen as less important tasks. However, i feel that TAs need to be trained in all aspects of the roles which they are expected to undertake. Cajkler, W., Suschitzky, W. (2007). Teamwork in the primary classroom. In J. Moyles (Ed.), Beginning Teaching Beginning Learning in Primary Education (pp. 181-191). Maidenhead: Open University Press. DfES. (2003). Raising standards and tackling workload: a national agreement. London: DfES. DfES. (2000, October). Working with Teaching Assistants. Retrieved March 8, 2010, from www.tda.gov.uk: http://www.tda.gov.uk/upload/resources/pdf/w/working_with_tas.pdf Giangreco, M. F., Doyle, M. B. (2007). Teaching assistants in inclusive schools. In L.Florian, The Sage Handbook of Special Education (pp. 429-439). London: Sage. Ofsted. (2002, April 16). Ofsted. Retrieved March 8, 2010, from Ofsted: https://ofsted3.openanswers.com/Ofsted-home/Publications-and-research/Browse-all-by/Education/Leadership/Management/Teaching-assistants-in-primary-schools-an-evaluation-of-the-quality-and-impact-of-their-work/(language)/eng-GB Times, T. (2008). Pupils using teaching assistants make less progress. Retrieved march 8, 2010, from Teaching Times: http://www.teachingtimes.com/articles/teaching-assistants-less-progress.htm

Guidance Counseling and Parental Involvement :: essays papers

Guidance Counseling and Parental Involvement The elementary school counseling and guidance program is part of the total school program and complements learning in the classroom. It is child-centered, preventive, and developmental. The program encourages students’ social, emotional, and personal growth at each stage of their development. The purpose of counseling with students, parents, and teachers is to help students maximize their potential. The elementary school counselor also conducts guidance lessons; consults with parents, teachers, and other professionals; and coordinates student services in the school (Gartner, Larson, & Allen, 1995). Counseling and guidance programs provides elementary students with assistance in: understanding self and developing a positive self-image, showing respect for the feelings of others, understanding the decision-making process, developing effective study skills, being prepared to make the transition to the intermediate school, and gaining an understanding of the world of work (Finney & Maloney, 1985; McCullough, 1995; Paloma & Pendelton, 1991). Counseling is conducted with students and parents individually and in small groups when requested and determined appropriate. It is short-term, voluntary, and confidential. Parental permission is obtained prior to any extended individual or group counseling. Students are seen by the counselor when: parents request and indicate a need and desire that the counselor meet with their children, students request counseling, and teachers, administrators, or other school staff refer the student. Parents are informed of counseling groups for children and adults. Group counseling sessions for children focus on building self-esteem, learning how to make or keep friends, developing good study habits, improving communication skills, preparing for the intermediate school, and coping with changing family situations. Topics for parent groups include child-rearing concerns, child development, and methods parents may use to help children experience healthy development and success in school (Aldridge, 1991; Friedman & Benson, 1997). The elementary school guidance counselor works with parents through individual consultation, joint consultation with the children’s teachers, and parents discussion groups. In these ways the counselor assist parents to: understand their children’s progress in school, select strategies to motivate their children, develop realistic goals with their children, become actively involved in their children’s school life, and understand the educational program K-12 (Byrd, 1988, p. 29). The counselor may lead parent education and discussion groups and serves as a resource when parents study or discuss child-related issues. The counselor consults with parents to identify students with special abilities and/or needs. In this capacity the counselor helps parents understand the services available from other school staff such as the school psychologists, social worker, and resource teachers.

Does The State Overstep Its Legitimate Function When It Prohibits Abortion :: essays research papers

Whether abortion is immoral or not, the state oversteps it’s legitimate function when it prohibits abortions. Here’s why:   Ã‚  Ã‚  Ã‚  Ã‚  When the state oversteps its boundaries and prohibits abortions it is denying our personal freedoms. We have the right to choose our own religions, jobs, schools and many other examples. But why can we not choose to have a baby aborted if we feel it’s necessary. For example, if a young lady in high school unfortunately gets pregnant, she should be able to make the decision to either have the baby or decide that she’s not ready to birth a child and have it aborted. Some people might say she should not have that choice, but who are they to make that decision.   Ã‚  Ã‚  Ã‚  Ã‚  In another case were the state oversteps it legitimate function when it prohibits abortions, is when a woman has been raped. With this circumstance should the woman be forced to have a kid that she did not want in the first place? If a woman is raped she should be able to choose an abortion because she was violated and has had a personal freedom taken from her already.   Ã‚  Ã‚  Ã‚  Ã‚  Some people might say, â€Å"It’s not that we don’t like abortion, it’s the issue of safety.† There have been cases of people dying or having serious medical problems due to the abortion procedure. Even with laws in place giving guidelines to doctors on the procedure, some doctors or unlicensed doctors still could injure a person, or even kill them. To think that is ludicrous, because a person could go to a licensed doctor that has statistics of his procedures.   Ã‚  Ã‚  Ã‚  Ã‚  Other people might say that abortion is murder. Abortion is the killing of a life that is starting to develop into a human being. With this circumstance, abortion should be treated as a crime and a punishment for that crime should be given.

Chemical Engineering

Theme : Electrical Sector and Chemical Engineer a) â€Å"The Chemical Engineer – His Role in Electrical Manufacturing† by N. R. Maleady The article is about the role of chemical engineer in manufacturing transformers in the electrical manufacturing sector. The important components of the transformer are copper wire, cellulosic insulation, insulating varnish and dielectric liquid. Wire enamel or resin is the insulting structure for copper wire. The resin can either applied as a solution or in solventless form.Mechanical arrangement and proper temperature between each dip are needed to be controlled to provide necessary multiple coats of resin to cure when resin is applied as a solution. Suitable dies and preheaters must be used when the resin is applied in solventless form to extrude the material on the moving wire. Cellulosic insulation is used to separate metal conducting parts. The cylinder on which the wire is wound is composed of continuously wound paper, bound toge ther by suitable impregnants and adhesives. To produce a stronger cylinder, modifications of the paper and adhensives and method of application are to be carried out.Insulating varnish is used in the treatment of components parts and assembled units to provide both insulation and mechanical strength. Viscosity of the material is ought to be maintained within certain limits and its electrical properties must be held at a high level through proper periodic filtration. A dielectric liquid – askarels (highly refined mineral oils and the newer non-inflammable insulating liquids) is used thoroughly free of air for insulating and cooling. Processing of assembled finished transformers is an important phrase of work in the transformer manufacture.Firstly, the insulated wire is wound about the cylinder. By applying heat to the unit while under vacuum, the high percentage of water, which is 8% of the weight of the cellulose present in cellulose insulation resulting in the low dielectric strength may be removed. Vacuum bake tank is used to provide rapid heating of the units through good air circulation, followed by removal of the absorbed water. By immersing the whole assembly into suitable insulating varnishes, which when cured, give it high mechanical strength to withstand the tremendous short circuit forces.Separate coils of wire are assembled and mounted on suitable laminated iron cores. The use of hot air baking and high vacuum resulting in high velocity air which cuts down the skin resistance of the insulation to heating and the heating-up time. When the final drying process which is free of both moisture and air have been completed, the dielectric fluid is run into the treating tank to completely immerse the coils for the absorption of water and allows the units to be handled before dropping into their own enclosures.The contributions of the chemical engineer are many and varied. In both the application of basic chemical knowledge and in the electrical desig n, the use of the chemical engineer principles and the solving skills in electrical manufacturing problems helped to supplement the specialized knowledge of the electric engineer in the processes involving physical and chemical changes.The cooperation of electrical engineers and chemical engineers has created many beneficial and useful tools in our life. b) â€Å"Getting students to approach microelectronics Processing as Chemical Engineer† by Koretsky et al. The article is about the ways of getting students to approach microelectronics processing as a chemical engineer. About 70% of the B. S. ChE graduates from Oregon State University (OSU) have been employed in the microelectronics industries.To enable the students to apply core ChE skills towards microelectronics processing, experiences in the microelectronics processing are being synthesized into the undergraduate program on four levels – Lab-based microelectronics unit operations, Options programs utilizing Thin F ilm Materials Processing (ChE 444/544), Multiple Engineering Co-op program (MECOP) Internship Program, and Undergraduate Research Projects and the University Honors College.In the lab-based microelectronics unit operations, there are six unit operations (Plasma Etching, Chemical Vapor Decomposition, Spin Coating, Electrochemical Decomposition, Silicon Oxidation and Chemical Mechanical Planarization) containing complex systems that involve the interaction of physical and chemical processes. Both lab-based and class room based instruction are carried out to reinforce the fundamental engineering science taught in the curriculum. Students are required to integrate into the lab based on the Unit Operations Laboratories (ChE 414 and 415) and Thin Film Materials Processing (ChE 444).The first quarter of the two-quarter senior lab sequence (ChE 414) focuses on the students to complete 3 unit operation experiments while the second quarter of the senior lab course (ChE 415) focuses on the stu dents to work independently, develop a project proposal, complete experimental work and write a final technical memorandum. Class room based instruction will give out example exercise or homework problems to be integrated into a core chemical engineering science or design course to draw upon core fundamentals.Some ABET criteria are also considered in the microelectronics unit operations so that the students can master both technical skills and professional practices (effective oral and written communications, project planning, time management, interpersonal interaction, teamwork, and proactive behavior). Students can choose the program they prefer from transcript visible Options in the microelectronics processing or material science and engineering, but Thin Film Materials Processing (ChE 444) is a must for the students.The course is to help the students to broaden and strengthen the undergraduate ChE curriculum. The Film Materials Processing (ChE 444) is mainly focusing on the appl ication of core chemical engineering sciences (transport. kinetics, thermodynamics and reactor design) to thin film process. This approach creates a mind set in the process engineer to apply engineering skills in problem solving. Guest seminars are important feature of this course. Popular industrial scientists are brought to share their industrial perspective and lectures in their areas of specialization.After the seminar, the students are required to submit a critical analysis on the talk to catalyze interest effectively and show the interaction between the speakers and the class. A Final Design Project consisting of a detailed design of an apparatus for a given thin film process, performed in teams, is a Final Exam for the students. Written report have to be prepared to explain and justify the design whereas oral presentation of the design is made to their classmates for critique.The Multiple Engineering Co-op program (MECOP) offers two six-month internship program at different c ompanies so that the student gets exposure to contrasting industrial environments. Written applications and an interview process are carried out when placing a student into an internship program. Second interview is held to focus on the students’ abilities and interests. There are midterm and final appraisals at the company where the intern is working.The intern’s performance and the company’s supervision are evaluated by the intern and the supervisor. The undergraduate research projects and the University Honors College (UHC) play a key role in getting students to approach microelectronics processing as a chemical engineer. Undergraduate research is to promote active learning. Undergraduates work with graduate students on independent, creative research projects to pursue independent long-term initiatives and to follow an idea to its logical conclusion.The University Honors College (UHC) Senior Thesis is not only a UHC curriculum, but an incredibly rewarding lea rning tool that provides the students with the skills to undertake similar projects in their Masters Program or career field. Chemical engineer is a professional skilled in the manufacture of chemical products. They use their specialized chemical knowledge and chemical engineer principles to create functional tools in our life.